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Dr. Kristine  Nolin
Dr. Kristine Nolin
Associate Professor of Chemistry
Profile

In the Nolin lab, we utilize data analytical tools to determine trends in the origin, structure and expression of biologically-active natural products, chemical compounds made by plants, animals, fungi, and bacterial. As a number of these compounds have been shown to have medicinal properties, we are working to streamline the discovery process.

Publications
Articles

"Convergence of glandular trichome morphology and chemistry in two montane monkeyflower species" Sofía Bustamante Eguiguren, Ha An Nguyen, Alexis Caldwell, Kristine A. Nolin, Carrie A. Wu Flora, 2020, 265, 151567, https://doi.org/10.1016/j.flora.2020.151567

Friedel-Crafts Alkylation of Benzo[b]furan with Activated Cyclopropanes Catalyzed by a Calcium(II) Complex”  Maloney, T. P.; Murphy, K. L.; Mainsah, T. L.; Nolin, K. A. Tetrahedron Lett. 2018, 59, 18-21.

“Calcium Catalyzed Mukaiyama-Mannich Addition of Silyl Enol Ethers to Nitrones”  Congdon, E. A.; Nolin, K. A. Catalysis Communications 2016, 79, 67-70.

Diastereoselective 1,3-Dipolar Cycloaddition of Nitrones to Donor–Acceptor Cyclopropanes Catalyzed by a Calcium(II) Complex”  Braun, C. M.; Congdon, E. A.; Nolin, K. A.  J. Org. Chem. 2015, 80, 1979-1984.

Dulin, C. C.; Murphy, K. L.; Nolin, K. A."Calcium-Catalyzed Friedel-Crafts Addition of 1-Methylindole to Activated Cyclopropanes" Tetrahedron Lett. 2014, 55, 5280-5282.

Badiceanu, A. D.; Garst, A. E.; Trubitt, M. E.; Nolin, K. A. "Addition of unactivated thiols to epoxides and oxetanes catalyzed by a rhenium-oxo complex" Catalysis Communications 2014, 47, 67-70.

Braun, C. M.; Shema, A. M.; Dulin, C. C.; Nolin, K. A. "Homologous Conjugate Addition of Thiols to Electron Deficient Cyclopropanes Catalyzed By a Calcium(II) Complex." Tetrahedron Lett 2013, 54, 5889?5891.

Garst, A. E.; Badiceanu, A. D.; Nolin, K. A. "Synthesis of ?-sulfanyl ketones via a tandem rearrangement-conjugate addition reaction catalyzed by a Re(V)-oxo complex." Tetrahedron Lett. 2013, 54, 459-461.

Peng, A.; Rosenblatt, R.; Nolin, K. "Conjugate addition of unactivated thiols to a,b-unsaturated ketones catalyzed by a bifunctional rhenium(V)–oxo complex" Tetrahedron Lett. 2012, 53, 2712-2714.

Nolin, K. A.; Ahn, R. W.; Kobayashi, Y.; Kennedy-Smith, J. J.; Toste, F. D. "Enantioselective Reduction of Ketones and Imines Catalyzed by (CN-Box)ReV–Oxo Complexes" Chem. Eur. J. 2010, 16, 9555-9562.

Nolin, K. A.; Krumper, J. R.; Bergman, R. G.; Toste, F. D. “Analysis of an Unprecedented Mechanism for the Catalytic Hydrosilylation of Carbonyl Compounds” Journal of the American Chemical Society 2007, 129, 14684-14696.

Nolin, K. A; Ahn, R. W.; Toste, F. D. “Enantioselective Reduction of Imines Catalyzed by a Rhenium (V)-Oxo Complex” Journal of the American Chemical Society 2005, 127, 12462-12463.

Kennedy-Smith, J. J.; Nolin, K. A.; Gunterman, H. P.; Toste, F. D. “Reversing the Role of the Metal-Oxygen -Bond. Chemoselective Catalytic Reductions with a Rhenium(V)-Dioxo Complex” Journal of the American Chemical Society 2003, 125, 4056-4057.

Education
Ph.D., University of California, Berkeley
Contact Information
C-310 Gottwald Center for the Sciences
(804) 289-8247
Areas of Expertise
Organic Chemistry