
Dr. Jeffrey I. Seeman
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Profile
Dr. Seeman's professional activities include research in the history and sociology of science including responsible conduct of research. He also produces and directs videos for educational and historical purposes.
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Selected Publications
Journal Articles
Effect of Conformational Change on Reactivity in Organic Chemistry Evaluations, Applications, and Extensions of Curtin-Hammett/Winstein-Holness Kinetics, Chem. Rev. 1983, 83, 83-134.
Recent Studies on Conformational Analysis and Steric Effects, Pure Appl. Chem. 1987, 59, 1661-1672.
The Woodward-Doering/Rabe-Kindler Total Synthesis of Quinine: Setting the Record Straight, Angew. Chem. Int. Ed., 2007, 46, 1378-1413.
Students Inspiring Students. An On-line Tool for Science Fair Participants, The Science Teacher, 2011, 78. 39-43 [with T. Lawrence].
Gilbert Stork: In his Own Words and in the Musings of his Friends, Angew. Chem. Int. Ed., 2012, 51, 3012-3023.
Guest Editorial: Estate Planning, Chemical & Engineering News, 2012, 90 (December 30), 3.
Having Fun with the Nozoe Autograph Books. A Bit of Exploration and an Unintended Learning Experience, The Chemical Record, 2013, 13, 146-160.
Carl Djerassi’s Search For Home. At 90, Highly Celebrated Chemist and Author Has a Burning Quest to Belong, Chemical & Engineering News, 2013, 91 (October 21), Front Cover, 10-11, 13-14.
Ernest L. Eliel, 1921 – 2008, Biographical Memoirs for the National Academy of Sciences, 2014, National Academy Press, Washington, D.C.; pp. 1-13,
http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/eliel-ernest.pdf.Conflict Resolution and Authorship Issues in the U.S. Chemical Academic Community [with Mark C. House], Accountability in Research, 2015, 22, 346-383.
Woodward-Hoffmann’s Stereochemistry of Electrocyclic Reactions: From Day 1 to the JACS Receipt Date (May 5, 1964 to November 30, 1964), J. Org. Chem. 2015, 80, 11632-11671.
John D. Roberts: In His Own Words and Those of His Friends, Angew. Chem. Int. Ed., 2015, 54, 15901-15913.
Wrong But Seminal, Nature Chemistry, 2016, 8, 193-200 [with S. Cantrill].
R. B. Woodward: A Larger Than Life Chemistry Rock Star, Angew. Chemie. Int. Ed. 2017, 56, 10228-10245.
Moving Past a Seminal Generation in the History of Chemistry, Bull. Hist. Chem. 2017, 42, 79-80.
A Model to Estimate the Sources of Tobacco Specific Nitrosamines in Cigarette Smoke, Chem. Res. Toxicol. 2017, 30, 1556-1561.
Synthesis and the Nobel Prize in Chemistry, Nature Chem. 2017, 9, 925-929.
Moving Beyond Insularity in the History, Philosophy, and Sociology of Chemistry, Found. Chem., 2018, 20, 75-86.
Multiple Independent Errors: A Parallelism to Robert K. Merton’s “Multiple Independent Discoveries”, Found. Chem. 2018, 20, 219-249.
On the Relationship between Classical Structure Determination and Retrosynthetic Analysis/Total Synthesis, Isr. J. Chem. 2018, 58, 28-44.
Peer Review of Mendeleev’s 1869 Breakthrough Paper: “I Suggest Eliminating the Table . . . ”, Helv. Chim. Acta 2019, 102, 4560-4564 (e1800177 (1-5)).
The Mutation of the “Nobel Prize in Chemistry” into the “Nobel Prize in Chemistry or Life Sciences”: Several Decades of Transparent and Opaque Evidence of Change within the Nobel Prize Program, Angew. Chemie Int. Ed., 2020, 59, 2942-2961 [with Guillermo Restrepo].
From Decades to Minutes. Steps Toward the Structure of Strychnine, 1910 – 1948, and the Application of Today’s Technology, Angew. Chemie. Int. Ed., 2020, 59, 10702-10721 [with D. Tantillo].
Rolf Huisgen, Eminent Chemist and Polymath (1920 – 2020) In His Own Words and In His Publication Metrics, Angew. Chemie. Int. Ed., 2020, 59, 12250-12266 [with G. Restrepo].
Rolf Huisgen’s Classic Studies of Cyclic Triene Diels-Alder Reactions Elaborated by Modern Computational Analysis, Angew. Chemie. Int. Ed., 2020, 59, 12506-12519 [with P.-P. Chen and K. N. Houk].
Evolution of the Diels-Alder Reaction Mechanisms Since the 1930s: Woodward, Houk with Woodward, and the Influence of Computational Chemistry on Understanding Cycloadditions, Angew. Chemie. Int. Ed., 2021, 60, 12660-12681 [with K. N. Houk, F. Liu, and Z. Yang]. https://doi.org/10.1002/anie.202001654.
“For its Size, the Most Complex Natural Product Known.” Who Deserves Credit for Determining the Structure of Strychnine? ACS Cent. Sci. 2022, 1-10; doi.org/10.1021/acscentsci.1c01348.
The Ways of Science Through the Lens of the Woodward-Hoffmann Rules. The Stories Begin, Chem. Rec., 2022, 22, 1-22; doi.org/10.1002/tcr.202100211.
A Sleeping Beauty in Chemistry. Oosterhoff, Havinga and Schlatmann, Four Years Before “The Woodward-Hoffmann Rules,” Chem. Rec., 2022, 22, 1-25; doi.org/10.1002/tcr.202100245.
Kenichi Fukui, Frontier Molecular Orbital Theory, and the Woodward-Hoffmann Rules. Part II. A Sleeping Beauty in Chemistry, Chem. Rec., 2022, 22, 1-30; doi.org/10.1002/tcr.202100300.
The Many Chemists Who Could Have Proposed the Woodward-Hoffmann Rules (Including Roald Hoffmann) But Didn’t: The Theoretical and Physical Chemists, Chem. Rec., 2022, 22, 1-45; doi.org/10.1002/tcr.202200052.
Five Decades of Dispute. A Triptych: Why Woodward? Chem. Rec., 2022, 22, 1-56; doi.org/10.1002/tcr.202200150.
Why Hoffmann? The Person and the Young Chemical Physicist, Chem. Rec., 2022, 22, 1-30; doi.org/10.1002/tcr.202200196.
The Many Chemists Who Could Have Proposed the Woodward-Hoffmann Rules But Didn’t: The Organic Chemists Who Discovered the Smoking Guns, Chem. Rec., 2022, 22, 1-67; doi.org/10.1002/tcr.202200065.
Percy Lavon Julian: A Man Who Rose to Every Occasion, Proc. Natl. Acad. Sci. U.S.A., 2022, 119, 1-4; e2208883119; doi.org/10.1073/pnas.2208883119.
Understanding Chemistry: From “Heuristic (Soft) Explanations and Reasoning by Analogy” to “Quantum Chemistry,” Chem. Sci., 2022, 11461-11486; doi: 10.1039/d2sc02535c [with Dean Tantillo].The Uncertain Role of Nominations in the Nobel Prize for Chemistry. Chem. Eur. J. 2023, 29, 1-15. DOI: 10.1002/chem.202203985 [with G. Restrepo].
Revolutions in Chemistry: Assessment of Six 20th Century Candidates (The Instrumental Revolution; Hückel Molecular Orbital Theory; Hückel’s 4n+2 Rule; the Woodward-Hoffmann Rules; Quantum Chemistry; and Corey’s Retrosynthetic Analysis), J. Am. Chem. Soc. Au, 2023, 3, 2378-2401; doi.org/10.1021/jacsau.3c00278.
Guest Editorial: Celebrating Carl Djerassi, Chem. Eng. News, 2023, 101 (October 23), 2; https://cen.acs.org/people/Guest-Editorial-Celebrating-Carl-Djerassi/101/i35 [with R. Hoffmann, B. Z. Shakhashiri, and R. N. Zare].
A 21st Century View of Allowed and Forbidden Electrocyclic Reactions, J. Org. Chem. 2024, 89, 1018-1034; https://doi.org/10.1021/acs.joc.3c02103 [with Q. Zhou, G. Kukier, I. Gordiy, R. Hoffmann, and K. N. Houk].