1996 – David A. Evans
Enantioselective Carbon-Carbon Bond Forming Reactions
Chiral cationic Cu(II) Lewis acid complexes are used for catalysis of the Diels Alder and aldol reactions. Both cycloaddition and aldol processes may now be efficiently catalyzed with enantioselectivities in excess of 90%. Issues pertaining to the structure of the catalyst-subtrate complexes, the problems of product inhibition, and the reaction scope for these reactions will be surveyed.