Dr. Lisa N. Gentile
Director, Academic Advising Resource Center
Associate Dean, School of Arts and Sciences
Associate Professor of Chemistry
Profile

In general, what I am most fascinated by is protein structure. More specifically, how that structure dictates function and biomolecular recognition, and what happens when that structure is altered in diseased states. The techniques that my group uses to monitor and determine protein structure are circular dichroism (CD), fluorescence, and nuclear magnetic resonance (NMR) spectroscopy. Students working in my lab are involved in the production of protein (cloning, mutagenesis, over-expression), its purification, and its biophysical characterization. I encourage interested students to come and talk with me.

Publications
Articles

*Cameron, K.; *Bartle, E.; *Roark, R.; *Fanelli, D.; *Pham, M.; *Pollard, B.; *Borkowski, B.; *Rhoads, S.; *Kim, J.; *Rocha, M.; *Kahlson, M.;*Kangala, M.; and Gentile, L.N. “Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors.”  Steroids, 2012, 77, 774.

*Fisher, S.; *Weck, M.; *Landers, J.; *Emrich, J.; *Middleton, S.; *Cox, J.; Gentile, L.N.; and Parish, C.A. “Theoretical and experimental evidence that the kinesin light chain is a tetratricopeptide repeat.” The Journal of Structural Biology, 2012,177, 602.

Gentile, L.;Caudill, L.; Fetea, M.; Hill, A.; Hoke, K.; Lawson, B.; Lipan, O.; Kerckhove, M.; Parish, C.; Stenger, K.; and Szajda, D. “Integrated Quantitative Science (IQS):  Teaching Concepts from Biology, Chemistry, Computer Science, Mathematics and Physics in a Year-Long Introductory Course for First Year STEM Majors.” Journal of College Science Teaching, 2012, 41, 24.

Gentile, L.N.; and Hoke, K. “Using Global Problems as a Basis for an Integrated STEM Course for First-Year Students.”   AAC&U Diversity & Democracy, 2011, 14, 2, 15.

*Raabe, R.; and Gentile, L.N." Antidepressant interactions with the NMDA NR1-1b subunit." Journal of Biophysics, Article ID 474205, 8 pages, 2008. doi:10.1155/2008/474205.
*Raabe, R.; and Gentile, L.N. "Thermal and chemical denaturation of Bacillus circulans xylanase: a biophysical chemistry laboratory module," Biochemistry and Molecular Biology Education, 36, 6, 428 (2008).
Hoke, K, and Gentile, L.N. "Early involvement in undergraduate research at the University of Richmond," CUR Quarterly, 29. 1, 18 (2008).
*Jeppesen, B.; *Costello, L.; *Fung, A.; *Stanley, E.; *McDonald, J.; *Lambert, A.; *Johnson, B.; and Gentile, L.N. "Structure nor stability of the transmembrane spanning 6/7 domain of Presenilin I correlates with pathogenicity." Biochemical and Biophysical Research Communications, 2007, 355, 820.
*Stoll, L.; *Seguin, S.; and Gentile, L.N. "Tricyclic antidepressents, but not the selective serotonin reuptake inhibitor fluoxetine, bind to the SIS2 domain of ionotropic glutamate receptors." Archives of Biochemistry and Biophysics, 2007, 458, 213.
*Stoll, L.; *Hall, J.; *Van Buren, N.; *Hall, A.; *Knight, l.; *Morgan, A.; *Zuger, S.; *Van Deusen, H.; and Gentile, L. "Differential regulation of ionotropic glutamate receptors." Biophysical Journal, 2007, 92, 1343.
Russo, S.; and Gentile, L.N. "Preparation, purification, and secondary structure determination of Bacillus circulans xylanase: a laboratory module incorporating aspects of molecular biology, biochemistry, and biophysical chemistry." Journal of Chemical Education, 2006, 83, 1850.
*Stoll, L.; and Gentile, L.N. "Linking tricyclic antidepressents to ionotropic glutamate receptors." Biochemical and Biophysical Research Communications, 2005, 333, 322.
*Spivak, V.; *Lin, A.; *Beebe, P.; *Stoll, L.; and Gentile, L.N. "Identification of a neurosteroid binding site contained within the GluR2-S1S2 domain." Lipids, 2004, 39, 811.
Campus Directory
Education
Ph.D., Brown University
Contact Information
003 Boatwright Memorial Library, Administrative Wing
(804) 484-1578
(804) 287-1897 (Fax)
111A Richmond Hall, Academic Advising Center
C-308 Department of Chemistry, Gottwald Center for the Sciences
Areas of Expertise
Biophysical Chemistry