Dr. William H. Myers
Professor of Chemistry
C-108 Gottwald Center for the Sciences
Office: (804) 289-8249
Fax: (804) 287-1897
http://facultystaff.richmond.edu/~wmyers/
Speciality:
Inorganic Chemistry
Teaching:
Inorganic Chemistry
Research:
Research in Professor Myers' laboratory proceeds in two principal areas. First, for some time we have had underway an investigation into the relationship between 1H NMR spectra and molecular crowding in highly hindered amine-borane compounds. The effort this year seeks to complete one major block of this work and will involve the synthesis of a specific group of methylpyridine complexes to confirm their identity through elemental analysis. As a byproduct, we expect to acquire on our new instrument more detailed NMR spectra (1H and other nuclei) on these compounds. Second, since 1990, we have been in a collaboration with a research group at the University of Virginia in an effort focused on the organic chemistry of pyrroles as modified by coordination to an osmium-amine complex. This summer, we were able to synthesize a molecule possessing the skeletal structure of a family of natural products, pyrrolizidines. This year, we will be investigating both alternative routes to molecules of this type and their derivative chemistry. There is a particular interest in this class of compounds since it includes a molecule which has shown potent anti-AIDS activity in initial tests.
Education:
Ph.D. - University of Florida
Selected Publications:
D.A. Delafuente, G.W. Kosturko, P.M. Graham, W.H. Harman, W.H. Myers, Y. Surendranath, R.C. Klet, C.O. Trindle, M. Sabat and W.D. Harman (2007) Isomerization Dynamics and Control of the η²/N Equilibrium for Pyridine Complexes. Journal of the American Chemical Society, 129, 406-416.
K.D. Welch, E.C. Lis, Jr., W. Liu, D.P. Harrison, R.J. Salomon, W.H. Myers and W. Dean Harman (2007) Large-Scale Syntheses of Several Synthons to the Dearomatization Agent {TpW(NO)(PMe3)} and Convenient Spectroscopic Tools for Product Analysis. Organometallics, 26, 2791-2794.
W. Liu, K. Welch, C.O. Trindle, M. Sabat, W.H. Myers and W.D. Harman (2007) Facile Intermolecular Aryl-F Bond Cleavage in the presence of Aryl C-H bonds. Organometallics, 26, 2589-2597.
K.C. Bassett, F. You, P. M. Graham, W.H. Myers, M. Sabat, W.D. Harman (2006) Furan [3 + 2] Dipolar Cycloadditions Promoted by a π-Basic Tungsten Metal Fragment. Organometallics, 25, 435-439.
Y. Surendranath, W.H. Myers and W.D. Harman (2006) Tungsten Promoted Dearomatization of Heterocycles: Uncovering the Latent 2-Azadiene Character of Pyrimidines. Organometallics, 25, 5852-5853.
K.D. Welch, P.L. Smith, A.P. Keller, W.H. Myers, M. Sabat andW.D. Harman (2006) Osmium(II)-, Rhenium(I)-, and Tungsten(0)-Promoted Dipolar Cycloaddition Reactions with Pyrroles: Exploiting the Azomethine Ylide Character of this Heterocycle. Organometallics, 25, 5067-5075.
E. Lis, W. Liu, M.A. Todd, W.H. Myers, D.A. Delafuente, Y. Lin, M. Sabat, C. Mocella and W.D. Harman (2006) The Uncommon Reactivity of Dihapto-Coordinated Nitrile, Ketone, and Alkene Ligands when Bound to a Powerful π-Base. Organometallics, 25, 5051-5058.
M.A. Todd, M. Grachen, W.H. Myers and W.D. Harman (2006) Common Electrophilic Addition Reactions at the Phenol Ring: the Chemistry of TpW(NO)(PMe3)(η²-phenol). Organometallics, 25, 3948-3954.
P.M. Graham, D.A. Delafuente, W. Liu, W.H. Myers, M. Sabat, W.D. Harman (2005) Facile Diels-Alder Reactions with Pyridines Promoted by Tungsten. Journal of the American Chemical Society, 127, 10568-10572.
D.A. Delafuente, W.H. Myers, M. Sabat, W.D. Harman (2005) Tungsten(0) η2-Thiophene Complexes: Dearomatization of Thiophene and Its Facile Oxidation, Protonation, and Hydrogenation. Organometallics, 24, 1876-1885.
M.T. Valohovic, W.H. Myers, and W.D. Harman (2002) Discrimination of Enantiofaces and Stereoselective Electrophilic Addition Reactions of η2-Pyrrole Complexes of Pentaammineosmium(II). Organometallics, 21, 4581-4589.
H. Chen, R. Caughey, R. Liu, M. McMills, M. Rupp, W.H. Myers, W.D. Harman (2000) Novel Cyclization Reactions for η2-Furan Complexes. Tetrahedron, 56, 2313-2323.
H. Chen, R. Liu, W.H. Myers, and W.D. Harman (1998) Dearomatization of Furan: Elementary Transformations of η2-Coordinated Furan Complexes of Pentaammineosmium(II). Journal of the American Chemical Society, 120, 509-520.
