Dr. Jonathan Dattelbaum
Assistant Professor of Chemistry
Co-coordinator, Biochemistry and Molecular Biology Program
D-300 Gottwald Center for the Sciences
Office: (804) 484-1587
Fax: (804) 287-1897
http://facultystaff.richmond.edu/~jdattelb/
Speciality:
Biochemistry
Teaching:
Introductory Chemistry
Biochemistry
Proteins structure, function, and biophysics
Research:
My research focuses on the design of fluorescent protein biosensors. One of the goals of my group is to design a biosensor for glucose. The constructed optical biosensor may be used to measure glucose concentrations in complex media such as blood serum. A second main project in my lab involves the characterization of a putative binding protein from Thermatoga maritima. a hyperthermophile. Finally, we collaborate with Dr. Malcolm Hill (Biology) isolating and characterizing secondary metabolites from common Chesapeake Bay sponges, Clathria prolifera and Halichondria bowerbanki.
Education:
Ph.D. - University of Maryland
Selected Publications:
*Luchansky, M.S., *Der, B.S., D’Auria, S., Pocsfalvi, G., Iozzino, L., Marasco, D., and Dattelbaum, J.D. (2009) Amino acid transport in thermophiles: characterization of an arginine-binding protein in Thermotoga maritima, Molecular BioSystems, in press.
*Vargo, M.L., *Gulka, C.P., *Gerig, J.K., *Manieri, C.M., Dattelbaum, J.D., Marks, C., *Lawrence, N.T., Trawick, M.L., and Leopold, M.C. (2009) Distance Dependence of Electron Transfer Kinetics for Azurin Protein Adsorbed to Monolayer Protected Nanoparticle Film Assemblies. Langmuir, in press.
*Der, B.S. and Dattelbaum, J.D. (2008) Construction of a Reagentless Glucose Biosensor using Molecular Exciton Luminescence, Analytical Biochemistry, 375, 132–140.
*Vercillo, N.C., *Herald, K.J., *Fox, J.F., *Der, B.S., and Dattelbaum, J.D. (2007) Analysis of Ligand Binding to a Ribose Biosensor using Site-directed Mutagenesis and Fluorescence Spectroscopy. Protein Science,16, 362-368.
Dattelbaum, J.D., Looger, L.L, Benson, D.E., Sali, K.M., Thompson, R.B., and Hellinga, H.W. (2005) Analysis of Allosteric Signal Transduction Mechanisms in an Engineered Fluorescent Maltose Biosensor, Protein Science, 14, 284-291.
Dattelbaum, J.D. Lockatell, V., Johnson, D., and Mobley, H.L.T. (2003) UreR, the transcriptional activator of the Proteus mirabilis urease gene cluster, is required for urease activity and virulence in experimental urinary tract infection, Infect. Immun., 171, 1026-1030.
Poore, C.A., Coker, C., Dattelbaum, J.D. and Mobley, H.L.T. (2001) Identification of the Domains of UreR, an AraC-like transcriptional Regulator of the Urease Gene Cluster in Proteus mirabilis, J. Bacteriol., 183, 4526-4535.
Dattelbaum, J.D. and Lakowicz, J.R. (2001) Optical Detection of Glutamine using a Genetically Engineered Protein. Anal. Biochem, 291, 89-95.
Piszczek, G., Maliwal, B.P., Gryczynski, I., Dattelbaum, J.D. and Lakowicz, J.R. (2001) Multi-photon Ligand-Enhanced Excitation of Lanthanides, J. Fluorescence, 11, 101-107.
Dattelbaum, J.D., Abugo, O., and Lakowicz, J.R. (2000) Characterization of a Sulfhydryl-Reactive Rhenium Metal-Ligand Complex. Bioconjugate Chem., 11, 533-36.
